Clinical outcomes after sentinel lymph node biopsy in clinically node-negative breast cancer patients
Identifieur interne : 002C44 ( Main/Exploration ); précédent : 002C43; suivant : 002C45Clinical outcomes after sentinel lymph node biopsy in clinically node-negative breast cancer patients
Auteurs : Hee Ji Han [Corée du Sud] ; Ju Ree Kim [Corée du Sud] ; Hee Rim Nam [Corée du Sud] ; Ki Chang Keum [Corée du Sud] ; Chang Ok Suh [Corée du Sud] ; Yong Bae Kim [Corée du Sud]Source :
- Radiation Oncology Journal [ 2234-1900 ] ; 2014.
Abstract
To evaluate non-sentinel lymph node (LN) status after sentinel lymph node biopsy (SNB) in patients with breast cancer and to identify the predictive factors for disease failure.
From January 2006 to December 2007, axillary lymph node (ALN) dissection after SNB was performed for patients with primary invasive breast cancer who had no clinical evidence of LN metastasis. A total of 320 patients were treated with breast-conserving surgery and radiotherapy.
The median age of patients was 48 years, and the median follow-up time was 72.8 months. Close resection margin (RM) was observed in 13 patients. The median number of dissected SNB was two, and that of total retrieved ALNs was 11. Sentinel node accuracy was 94.7%, and the overall false negative rate (FNR) was 5.3%. Eleven patients experienced treatment failure. Local recurrence, regional LN recurrence, and distant metastasis were identified in 0.9%, 1.9%, and 2.8% of these patients, respectively. Sentinel LN status were not associated with locoregional recurrence (p > 0.05). Close RM was the only significant factor for disease-free survival (DFS) in univariate and multivariate analysis. The 5-year overall survival, DFS, and locoregional DFS were 100%, 96.8%, and 98.1%, respectively.
In this study, SNB was performed with high accuracy and low FNR and high locoregional control was achieved.
Url:
DOI: 10.3857/roj.2014.32.3.132
PubMed: 25324984
PubMed Central: 4194295
Affiliations:
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General Hospital, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Radiation Oncology, Cheil General Hospital, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Nam, Hee Rim" sort="Nam, Hee Rim" uniqKey="Nam H" first="Hee Rim" last="Nam">Hee Rim Nam</name><affiliation wicri:level="3"><nlm:aff id="A3">Department of Radiation Oncology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Radiation Oncology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Keum, Ki Chang" sort="Keum, Ki Chang" uniqKey="Keum K" first="Ki Chang" last="Keum">Ki Chang Keum</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Suh, Chang Ok" sort="Suh, Chang Ok" uniqKey="Suh C" first="Chang Ok" last="Suh">Chang Ok Suh</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" 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type="wicri:Area/Main/Curation">002C44</idno><idno type="wicri:Area/Main/Exploration">002C44</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Clinical outcomes after sentinel lymph node biopsy in clinically node-negative breast cancer patients</title><author><name sortKey="Han, Hee Ji" sort="Han, Hee Ji" uniqKey="Han H" first="Hee Ji" last="Han">Hee Ji Han</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Ju Ree" sort="Kim, Ju Ree" uniqKey="Kim J" first="Ju Ree" last="Kim">Ju Ree Kim</name><affiliation wicri:level="3"><nlm:aff id="A2">Department of Radiation Oncology, Cheil General Hospital, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Radiation Oncology, Cheil General Hospital, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Nam, Hee Rim" sort="Nam, Hee Rim" uniqKey="Nam H" first="Hee Rim" last="Nam">Hee Rim Nam</name><affiliation wicri:level="3"><nlm:aff id="A3">Department of Radiation Oncology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Radiation Oncology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Keum, Ki Chang" sort="Keum, Ki Chang" uniqKey="Keum K" first="Ki Chang" last="Keum">Ki Chang Keum</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Suh, Chang Ok" sort="Suh, Chang Ok" uniqKey="Suh C" first="Chang Ok" last="Suh">Chang Ok Suh</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Yong Bae" sort="Kim, Yong Bae" uniqKey="Kim Y" first="Yong Bae" last="Kim">Yong Bae Kim</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author></analytic><series><title level="j">Radiation Oncology Journal</title><idno type="ISSN">2234-1900</idno><idno type="eISSN">2234-3164</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Purpose</title><p>To evaluate non-sentinel lymph node (LN) status after sentinel lymph node biopsy (SNB) in patients with breast cancer and to identify the predictive factors for disease failure.</p></sec><sec><title>Materials and Methods</title><p>From January 2006 to December 2007, axillary lymph node (ALN) dissection after SNB was performed for patients with primary invasive breast cancer who had no clinical evidence of LN metastasis. A total of 320 patients were treated with breast-conserving surgery and radiotherapy.</p></sec><sec><title>Results</title><p>The median age of patients was 48 years, and the median follow-up time was 72.8 months. Close resection margin (RM) was observed in 13 patients. The median number of dissected SNB was two, and that of total retrieved ALNs was 11. Sentinel node accuracy was 94.7%, and the overall false negative rate (FNR) was 5.3%. Eleven patients experienced treatment failure. Local recurrence, regional LN recurrence, and distant metastasis were identified in 0.9%, 1.9%, and 2.8% of these patients, respectively. Sentinel LN status were not associated with locoregional recurrence (p > 0.05). Close RM was the only significant factor for disease-free survival (DFS) in univariate and multivariate analysis. The 5-year overall survival, DFS, and locoregional DFS were 100%, 96.8%, and 98.1%, respectively.</p></sec><sec><title>Conclusion</title><p>In this study, SNB was performed with high accuracy and low FNR and high locoregional control was achieved.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Veronesi, U" uniqKey="Veronesi U">U Veronesi</name></author><author><name sortKey="Paganelli, G" uniqKey="Paganelli G">G Paganelli</name></author><author><name sortKey="Galimberti, V" uniqKey="Galimberti V">V Galimberti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krag, Dn" uniqKey="Krag D">DN Krag</name></author><author><name sortKey="Anderson, Sj" uniqKey="Anderson S">SJ Anderson</name></author><author><name sortKey="Julian, Tb" uniqKey="Julian T">TB Julian</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Veronesi, U" uniqKey="Veronesi U">U 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Kroon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goodwin, P" uniqKey="Goodwin P">P Goodwin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miltenburg, Dm" uniqKey="Miltenburg D">DM Miltenburg</name></author><author><name sortKey="Miller, C" uniqKey="Miller C">C Miller</name></author><author><name sortKey="Karamlou, Tb" uniqKey="Karamlou T">TB Karamlou</name></author><author><name sortKey="Brunicardi, Fc" uniqKey="Brunicardi F">FC Brunicardi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ban, Ej" uniqKey="Ban E">EJ Ban</name></author><author><name sortKey="Lee, Js" uniqKey="Lee J">JS Lee</name></author><author><name sortKey="Koo, Js" uniqKey="Koo J">JS Koo</name></author><author><name sortKey="Park, S" uniqKey="Park S">S Park</name></author><author><name sortKey="Kim, Si" uniqKey="Kim S">SI Kim</name></author><author><name sortKey="Park, Bw" uniqKey="Park B">BW Park</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Corée du Sud</li></country><region><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li></settlement></list><tree><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Han, Hee Ji" sort="Han, Hee Ji" uniqKey="Han H" first="Hee Ji" last="Han">Hee Ji Han</name></region><name sortKey="Keum, Ki Chang" sort="Keum, Ki Chang" uniqKey="Keum K" first="Ki Chang" last="Keum">Ki Chang Keum</name><name sortKey="Kim, Ju Ree" sort="Kim, Ju Ree" uniqKey="Kim J" first="Ju Ree" last="Kim">Ju Ree Kim</name><name sortKey="Kim, Yong Bae" sort="Kim, Yong Bae" uniqKey="Kim Y" first="Yong Bae" last="Kim">Yong Bae Kim</name><name sortKey="Nam, Hee Rim" sort="Nam, Hee Rim" uniqKey="Nam H" first="Hee Rim" last="Nam">Hee Rim Nam</name><name sortKey="Suh, Chang Ok" sort="Suh, Chang Ok" uniqKey="Suh C" first="Chang Ok" last="Suh">Chang Ok 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